C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/1.10
C12N 15/30 (2006.01) A61K 39/012 (2006.01) A61K 39/395 (2006.01) C07K 1/14 (2006.01) C07K 14/455 (2006.01) C07K 16/20 (2006.01) C07K 16/42 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1340520
A purified antigenic protein has been obtained which is capable of inducing in a chicken an immune response confering protection against infection by Eimeria tenella or Eimeria necatrix. The protein has a molecular weight of about 25,000 and is composed of two polypeptides joined by a disulfide bond. The two polypeptide subunits have molecular weights of about 17,000 and about 8,000, respectively. The gene encoding the protein has been sequenced and the amino acid sequence of the protein deduced therefrom and by direct peptide sequencing. The protein and antigenic polypeptides having an amino acid sequence included within the protein may be incorporated into a vaccine for conferring upon a chicken active immunity against infection by E. tenella and E. necatrix. A hybridoma cell line (ATCC No. HB8561) has been developed which produces a monoclonal antibody designated Ptn 7.2A4/4. This antibody may be used to confer upon a chicken specific passive protection against infection by E. tenella and E. necatrix. The antibody may also be used to obtain the purified protein antigen and the 11,500 and 6,500 dalton polypeptide fragments thereof. Finally, an anti-idiotype antibody to the Ptn 7.2A4/4 monoclonal antibody may be prepared and used to confer upon a chicken active immunity against E. tenella and E. necatrix infection.
483147
Brothers Virginia Mary
Files James Gordon
Gore Thomas C.
Newman Karel Z. Jr.
Paul Lelan Shawn
Dimminaco Ag/sa/ltd.
Robic
Solvay & Cie
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