C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/129, 195/1.1
C12N 15/30 (2006.01) A61K 39/012 (2006.01) C07K 14/455 (2006.01) C07K 16/20 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1341166
Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix, Eimeria tenella or Eimeria maxima. One protein, useful for conferring protection against E. tenella and E. necatrix, has been derived from sporocysts of E. tenella. Other proteins, derived from merozoites of E. maxima, are useful for conferring protection against E. maxima. Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis. Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences included within these proteins are also provided. Moreover, multi-component vaccines which comprises admixtures of Eimeria antigens or isotopes are disclosed.
524333
Andrews William H.
Brothers Virginia M.
Chang Ray-Jen
Dragon Elizabeth A.
Files James G.
Dimminaco Ag/sa/ltd.
Robic
Solvay & Cie
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