Antigenic targets of autoimmune sensorineural hearing loss...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/705 (2006.01) A61K 31/00 (2006.01) A61K 39/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2489275

This invention relates generally to antigens reactive with autoantibodies associated with autoimmune sensorineural hearing loss (AISNHL), and in particular relates to a novel antigen, Inner Ear Supporting Cell Antigen (IESCA) reactive with autoantibodies associated with autoimmune sensorineural hearing loss (AISNHL), and to methods for the detecting therapeutic outcomes in treatment of AISNHL patients, and to methods of detecting genetic lesions in genes encoding for such antigens.

L'invention concerne, d'une mani­re g~n~rale, des antig­nes r~actifs aux autoanticorps associ~s ~ la surdit~ de perception auto-immune (AISNHL) et, plus pr~cis~ment, un antig­ne, l'antig­ne des cellules de soutien de l'oreille interne (IESCA), r~actif aux autoanticorps associ~s ~ la surdit~ de perception auto-immune (AISNHL), ainsi que des m~thodes de d~tection de r~sultats th~rapeutiques dans le traitement de patients souffrant de AISNHL et des m~thodes de d~tection de l~sions g~n~tiques dans des g­nes codant de tels antig­nes.

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