Antigens associated with endometriosis, psoriatic arthritis...

A - Human Necessities – 61 – K

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A61K 51/10 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) G01N 33/53 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2748401

Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, and/or for use in delivery to the neovasculature of endometriotic tissue of a molecule conjugated to the specific binding member. Specific binding members that bind tenascin-C, especially the A1 A2, A3, A4 and/or D domain tenascin-C large isoform, for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, psoriatic athritis or psoriasis, and/or for use in delivery to the neovasculature of endometriotic, psoriatic arthritic or psoriatic tissue of a molecule conjugated to the specific binding member.

L'invention concerne des éléments de liaison spécifique qui se lient à l'isoforme ED-A de la fibronectine à utiliser dans des méthodes pour le diagnostic, la détection, l'imagerie et/ou le traitement de l'endométriose, et/ou à utiliser dans l'administration au système néovasculaire des tissus endométriotiques d'une molécule conjuguée à l'élément de liaison spécifique. Les éléments de liaison spécifique qui se lient à la ténascine-C, en particulier les domaines A1, A2, A3, A4 et/ou D de la grande isoforme de ténascine-C, à utiliser dans des méthodes pour le diagnostic, la détection, l'imagerie et/ou le traitement de l'endométriose, le rhumatisme psoriasique ou le psoriasis, et/ou à utiliser dans l'administration au système néovasculaire des tissus endométriotiques, de rhumatisme psoriasique ou prosiasiques d'une molécule conjuguée à l'élément de liaison spécifique.

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