C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) G01N 33/564 (2006.01)
Patent
CA 2264019
The invention concerns an artificial antigen specifically identified by the anti-filaggrin autoantibodies present in the serum of patients suffering from rheumatoid polyarthritis, and consisting of one polypeptide comprising all or part of the sequence of one filaggrin unit or of a related molecule, in which an arginine radical has been substituted by a citrulline radical. The invention also concerns the use of this antigen for diagnosing rheumatoid polyarthritis.
L'invention est relative à un antigène artificiel reconnu spécifiquement par les auto-anticorps anti-filaggrine présents dans le sérum de patients atteints de polyarthrite rhumatoïde, et constitué par un polypeptide comprenant tout ou partie de la séquence d'une unité filaggrine ou d'une molécule apparentée, dans laquelle au moins un résidu arginine a été substitué par un résidu citrulline. L'invention est également relative à l'utilisation de cet antigène pour le diagnostic de la polyarthrite rhumatoïde.
Arnaud Michel
Dalbon Pascal
Girbal-Neuhauser Elisabeth
Jolivet Michel
Jolivet-Reynaud Colette
Biomerieux
Robic
LandOfFree
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