Antigens of plasmodium falciparum

C - Chemistry – Metallurgy – 12 – N

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C12N 15/30 (2006.01) A61K 39/015 (2006.01) C07K 7/06 (2006.01) C07K 14/445 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1340213

DNA molecules comprising artificially constructed polynucleotide sequences substantially corresponding to all or a portion of the base sequence coding for an antigen of Plasmodium falciparum selected from the group consisting of the RESA antigen, the FIRA antigen, and other antigens of P.falciparum cross-reactive therewith. Such DNA molecules are capable of being expressed as polypeptide(s). Synthetic peptides or polypeptides displaying the antigenicity of all or a portion of the RESA or FIRA antigens of P.falciparum. Compositions for stimulating immune responses against P.falciparum antigens in a mammal, comprising at least one polypeptide displaying the antigenicity of the RESA or FIRA antigens of P.falciparum, together with a pharmaceutically acceptable carrier therefor.

490460

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