Antigens that elicit immune response against flavivirus and...

Details Antigens that elicit immune response against flavivirus and... Antigens that elicit immune response against flavivirus and...

C - Chemistry, Metallurgy

12

N

C12N 15/40 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) A61P 31/14 (2006.01) A61P 37/04 (2006.01) C07K 14/18 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2740598

Aspects of the present invention relate to isolated nucleic acids that encode a consensus DIII domain of protein E and vaccines made using same, and also methods for using the aforementioned to generate in a host an immune response against multiple serotypes of flavivirus, particularly West Nile virus and Japanese encephalitis virus.

Des aspects de la présente invention concernent des acides nucléiques isolés qui codent pour un domaine consensus DIII de protéine E et des vaccins préparés en utilisant ceux-ci, ainsi que des procédés pour utiliser ceux-ci pour générer chez un hôte une réponse immunitaire contre des sérotypes multiples de flavivirus, en particulier le virus du Nil occidental et le virus de lencéphalite japonaise.

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