Antiherpes pentapeptide derivatives having a cycloalkyl...

Details Antiherpes pentapeptide derivatives having a cycloalkyl... Antiherpes pentapeptide derivatives having a cycloalkyl...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 7/40 (1990.01)

Patent

CA 2019005

Disclosed herein are pentapeptide derivatives of the formula X-NR1-CH(R2)-C(W1)-NH-CR3(R4)-C(W2)-NR5-CH[CH2C(O)-Y]- C(W3)-NH-CR6-[CR7(R8)-COOH]-C(W4)-NH-CR9(R10-Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R1 is hydrogen, alkyl or phenylalkyl, R2, R4 and R10 are selected from amino acid or derived amino acid residues, R3, R5, R6 and R9 are hydrogen or alkyl, R7 and R8 are joined to form a cycloalkyl, W1, W2, W3 and W4 are oxo or thioxo, Y is, for example, an alkoxy or a mono or disubstituted amino, and Z is a terminal group, for example, COOH or CH2OH. The derivatives are useful for treating herpes infections.

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