C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/103.05, 530/
C07K 7/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07K 5/103 (2006.01) C07K 14/035 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1340684
Disclosed herein are pentapeptide derivatives of the formula XNR1-CH(R2)-C(O)-NH-CH(R3)-C(O)-NR4-CH(CH2Y)-CO- NH-CH[CR5(R6)-COOH]-C(W)-NH-CH(R7)-Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R1 is alkyl or phenylalkyl, R2, R3 and R7 are selected from amino acid or derived amino acid residues, R4, R5, and R6 are hydrogen or lower alkyl, W is oxo or thioxo, Y is carboxy, carbamyl or 5-1H-tetrazolyl and Z is carboxy or 5-1H-tetrazolyl. The derivatives are useful for treating herpes infections.
605092
Adams Julian
Beaulieu Pierre Louis
Lavallee Pierre
Plante Raymond
Rakhit Sumanas
Bio-Mega Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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