Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus

Details Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus

C - Chemistry, Metallurgy

07

K

167/300, 530/5.0

C07K 5/08 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07K 5/06 (2006.01) C07K 5/072 (2006.01) C07K 5/093 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2018801

Disclosed herein are peptide derivatives of the formula R1NH-CO-Q-C(O)-NR2-CH[CH2C(O)-Y]-C(O)-NH-CH[CR3(R4)-COOH]- C(W)-NH-CHR5-Z wherein R1 is an optionally substituted alkyl or optionally substituted phenylalkyl, R2 is hydrogen or alkyl, R3 and R4 each independently is hydrogen or alkyl, or R3 and R4 are joined to form a cycloalkyl, R5 is alkyl, cycloalkyl or (cycloalkyl)alkyl, Q is a divalent radical, for example, -CH2CH2-, -CH=CH- or 1,2-cyclohexanediyl, which serves as a two carbon spacer, W is oxo or thioxo, Y is, for example, an alkoxy or a monosubstituted or disubstituted amino, and Z is a terminal unit, for example, hydrogen, COOH or CH2OH. The derivatives are useful for treating herpes infections.

Affiliated with

Also associated with

Rating

Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1632937