Antiherpes peptidomimetic compounds

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 271/22 (2006.01) C07C 275/16 (2006.01)

Patent

CA 2230750

Disclosed herein are intermediates of the formula W1-Tbg-CH2-(R)-CH(CH2C(O)CMe3)C(O)OW2 wherein W1 is an amino protective group and W2 is a carboxyl protective group. Also disclosed is a stereospecific process for preparing the intermediates. The intermediates can be converted to antiviral compounds useful for treating herpes infection; for instance compounds of the formula: Image wherein R1 is (1-3C)alkyl, R2 is hydrogen or (1-3C)alkyl and R3 is (1-3C)alkyl.

L'invention porte sur des intermédiaires de formule W1-Tbg-CH2-(R)- CH(CH2C(O)CMe3)C(O)OW2, où W1 est un groupe amine protecteur et W2 un groupe carboxyle protecteur. L'invention présente également une méthode stéréospécifique pour préparer ces intermédiaires. Ceux-ci peuvent être convertis en composés antiviraux, utiles pour le traitement des infections herpétiques, comme par exemple les composés de formule Image , où R1 est un alkyle (1-3C), R2 est un hydrogène ou un alkyle (1-3C) et R3 est un alkyle (1-3C).

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