Antiherpes tetrapeptides having a substituted aspartic acid...

Details Antiherpes tetrapeptides having a substituted aspartic acid... Antiherpes tetrapeptides having a substituted aspartic acid...

C - Chemistry, Metallurgy

07

K

167/300, 167/103

C07K 5/103 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) C07K 5/02 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C07K 5/107 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340681

Disclosed herein are tetrapeptide derivatives of the formula X-NH-CHR1-C(W1)-NR2-CH[CH2C(O)-Y]-C(W2)-NH-CH- [CR3(R4)-COOH]-C(W3)-NH-CHR3-Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R1 and R5 are selected from amino acid or derived amino acid residues, R2 is hydrogen, alkyl or phenylalkyl, R3 and R4 are hydrogen or lower alkyl, W1, W2 and W3 are oxo or thioxo, Y is, for example, an alkoxy or a monosubstituted or disubstituted amino, and Z is a terminal group, for example, COOH or CH2OH. The derivatives are useful for treating herpes infections.

605061

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