Antihypercholesterolemic .beta.-lactones

Details Antihypercholesterolemic .beta.-lactones Antihypercholesterolemic .beta.-lactones

C - Chemistry, Metallurgy

07

D

167/243, 260/368

C07D 305/12 (2006.01) A61K 31/365 (2006.01) C07D 407/06 (2006.01)

Patent

CA 1284333

TITLE OF THE INVENTION ANTIHYPERCHOLESTEROLEMIC .beta.-LACTONES ABSTRACT OF THE DISCLOSURE The compounds of the following general structural formula (I) Image ( I ) are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihyper- cholesterolemic agents for the treatment of disease in which the inhibition of cholesteroi biosynthesis would be useful, such as arteriosclerosis, hyper- lipidemia and familial hypercholesterolemia.

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