Antihypercholesterolemic compounds and related...

C - Chemistry – Metallurgy – 07 – J

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C07J 71/00 (2006.01) A61K 31/56 (2006.01) A61K 31/58 (2006.01) A61P 3/06 (2006.01) C07J 9/00 (2006.01) C07J 53/00 (2006.01)

Patent

CA 2134222

2134222 9325568 PCTABS00028 Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has structural formula (I), wherein R is a C-17 side chain, R1 is -OH, =O, or the like, R8 and R9 are independently hydrogen or lower alkyl, and X and Y are N, N$m(8)O, CH, C-OH, C-OCH3 or C-Z. Methods of using the compound of formula (I) or other novel oxysterol analogs to treat hypercholesterolemia are provided, as are pharmaceutical compositions containing the compounds.

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