C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 71/00 (2006.01) A61K 31/56 (2006.01) A61K 31/58 (2006.01) A61P 3/06 (2006.01) C07J 9/00 (2006.01) C07J 53/00 (2006.01)
Patent
CA 2134222
2134222 9325568 PCTABS00028 Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has structural formula (I), wherein R is a C-17 side chain, R1 is -OH, =O, or the like, R8 and R9 are independently hydrogen or lower alkyl, and X and Y are N, N$m(8)O, CH, C-OH, C-OCH3 or C-Z. Methods of using the compound of formula (I) or other novel oxysterol analogs to treat hypercholesterolemia are provided, as are pharmaceutical compositions containing the compounds.
Avery Mitchell A.
Chao Wan-Ru
Chong Wesley K. M.
Johansson John G.
Tanabe Masato
Gowling Lafleur Henderson Llp
Sri International
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