C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 71/00 (2006.01) A61K 31/575 (2006.01) A61P 3/00 (2006.01) C07D 261/20 (2006.01) C07J 9/00 (2006.01)
Patent
CA 2418594
Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has the structural formula (I): (See formula I) wherein R is a C-17 side chain, R1 is -OH, =O, or the like, R8 and R9 are independenly hydrogen or lower alkyl, and X and Y are N, N.fwdarw.O, CH, C-OH, C-OCH3 or C-Z. Methods of using the compound of formula (I) or other novel oxysterol analogs to treat hypercholesterolemia are provided, as are pharmaceutical compositions containing the compounds.
Avery Mitchell A.
Chao Wan-Ru
Chong Wesley K.m.
Johansson John G.
Tanabe Masato
Gowling Lafleur Henderson Llp
Sri International
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