C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/312, 260/304
C07D 257/04 (2006.01) C07D 405/06 (2006.01)
Patent
CA 1328268
ABSTRACT Compounds of the formula Image I wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, or trifluoro- methyl; R2, R3, R5 and R6 each are independently hydrogen, halogen C1-4 alkyl of C1-4 alkoxy; tet is Image or Image ; n is an integer of from 0 to 2, inclusive; A is Image or Image ; R7 is hydrogen, C1-4 alkyl, C1-4 alkoxy(lower) alkyl or (2-methoxyethoxy)methyl; X is -OH or =O; and R8 is hydrogen, a hydrolyzable ester group or a cation to form a non-toxic pharmaceuti- cally acceptable salt, are novel antihypercholesterolemic agents which inhibit cholesterol biosynthesis. Intermediates and processes for their preparation are disclosed.
559667
Sit Sing-Yuen
Wright John J.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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