C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/251, 260/266
C07D 403/06 (2006.01) C07D 207/24 (2006.01) C07D 207/26 (2006.01) C07D 233/36 (2006.01) C07D 233/42 (2006.01) C07D 235/26 (2006.01) C07D 239/36 (2006.01) C07D 239/40 (2006.01) C07D 239/96 (2006.01) C07D 263/22 (2006.01) C07D 413/06 (2006.01)
Patent
CA 1247098
INDANE DERIVATIVES AND METHOD OF TREATMENT ABSTRACT OF THE DISCLOSURE The present invention relates to indane derivatives with the following formula: Image I wherein R1 is H, Halogen, an alkyl group having from one to three carbon atoms inclusive, methoxy, a methylthio-group, or a trifluoromethyl group, n is 2 - 4, X is O or S, Y is O, CH2 or N-R2, where R2 is hydrogen or an (1-6 C) alkyl, (1-6 C) alkenyl or cycloalkyl-methyl group having from three to six carbon atoms, Z is -(CH2)n-, n is 2 or 3 or Z is 1,2-phenylene optionally substituted with halogen or trifluoromethyl or Z = 1,2-C6H4CO- (to form a quinazolidinone or -thione ring system). U = N or C. Each compound exists as geometric isomers and each of these as a pair of optical isomers; and the separation and isolation of these are also within the Moreover, pharmaceutically acceptable acid addition salts of the compounds of Formula I are within the scope of the present invention. Pharmaceutical compositions containing a compound of Formula I or a salt thereof as an active ingredient, and methods for the treatment of hypertension and other cardiovascular diseases as well as anxiety, by administration of a therapeutically active amount of one of the compounds of Formula I to a living animal body, including human beings, fall within the scope of the present invention.
492870
Gastle And Associates
Lundbeck (h.) A/s
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