Antihypertensive amides

Details Antihypertensive amides Antihypertensive amides

C - Chemistry, Metallurgy

07

D

260/471, 260/507

C07D 333/48 (2006.01) C07D 207/08 (2006.01) C07D 211/26 (2006.01) C07D 213/40 (2006.01) C07D 213/75 (2006.01) C07D 217/22 (2006.01) C07D 219/14 (2006.01) C07D 235/30 (2006.01) C07D 239/42 (2006.01) C07D 277/46 (2006.01) C07D 307/52 (2006.01) C07D 307/66 (2006.01) C07D 307/82 (2006.01) C07D 309/14 (2006.01) C07D 317/66 (2006.01) C07D 319/18 (2006.01) C07D 333/20 (2006.01) C07D 333/36 (2006.01)

Patent

CA 1175848

ABSTRACT OF THE DISCLOSURE Compounds of the structure Image wherein R1, R2, R3 and R4 are independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, or phenyl-lower alkyl, wherein the lower alkyl, lower alkenyl and lower alkynyl groups have up to 6 carbon atoms, n is an integer from 1 to 5 inclusive; M is cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl, fused acrylcyloalkyl, phenyl, lower alkylphenyl, hydroxyphenyl, methlenedioxyphenyl, bicycloalkyl-lower alkyl, halophenyl or alkylthiophenyl and contains from 3-16 carbon atoms, Y is hydroxy, lower alkoxy having 1 to 6 carbon atoms or amino, R5 is hydrogen, lower alkanoyl, benzoyl, Z5 or Image wherein the lower alkanoyl contains up to 6 carbon atoms, Z is hydrogen, lower alkyl, hydroxy-lower alkyl, amino-lower alkyl, or a radical of the formula Image wherein R1, R2, R3, and R4 n, M and Y are as defined above. Also disclosed are non-toxic, pharmaceutically acceptable alkali metal, alkaline earth metal and amine salts where y is hydroxy. The compounds are useful in reducing the blood pres- sure in mammals having hypertension.

355587

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