Antihypertensive combination

Details Antihypertensive combination Antihypertensive combination

A - Human Necessities

61

K

A61K 31/55 (2006.01)

Patent

CA 2074039

Antihypertensive combination preparation containing a tetrahydronaphthalene derivative of the general formula <See formula I> wherein R1 signifies halogen, R2 signifies lower-alkoxy- lower-alkylcarbonyloxy, X signifies C2-C8-alkylene and A signifies benzimidazolyl optionally substituted at the N atom by alkyl with 1 to 12 C atoms, and a pyridazodiazepine of the general formula <See formula II> wherein R4 signifies aralkyl with 1 to 6 C atoms in the alkyl residue and phenyl, which is optionally mono-substituted by halogen, alkoxy with 1 to 6 C atoms or phenyl, as the aryl residue, R5 and R6 each independently signify hydrogen or alkyl with 1 to 6 C atoms and R7 and R8 each signify hydrogen or together signify an oxo group, in the form of their free bases, their hydrates or their pharmaceutically usable salts for the simultaneous, separate or planned stepwise use.

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