A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/165 (2006.01) A61K 31/505 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2677822
Therapeutic combinations and pharmaceutical compositions are provided comprising darusentan and an inhibitor of renin activity or release in absolute and relative amounts effective to provide a beneficial change in a subject's 24-hour pattern of systolic and/or diastolic blood pressure. There are further provided methods of using such combinations or compositions to treat hypertensive disorders, or to lower blood pressure in subjects exhibiting resistance to a baseline antihypertensive therapy.
L'invention concerne des combinaisons thérapeutiques et des compositions pharmaceutiques comprenant du darusentan et un inhibiteur d'activité ou de libération de rénine en des quantités absolues et relatives efficaces pour apporter un changement salutaire dans le modèle de pression artérielle systolique et/ou diastolique d'un patient sur une durée de 24 heures. L'invention concerne en outre des procédés d'utilisation de telles combinaisons ou compositions pour traiter des troubles de l'hypertension, ou pour diminuer la pression artérielle chez des sujets présentant une résistance à un traitement antihypertenseur de base.
Gilead Colorado Inc.
Mcfadden Fincham
LandOfFree
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