A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/395 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61K 31/5513 (2006.01) A61K 31/553 (2006.01) A61K 31/554 (2006.01)
Patent
CA 2160092
An antihypertriglyceridemic composition comprising a compound of formula (I) Image (I) wherein R1 represents a hydrogen atom or a hydrocarbon group that may be substituted; R2 and R3 may be the same or different and each represents a hydrogen atom, a hydrocarbon group that may be substituted, or a heterocyclic group that may be substituted; X' represents a substituent comprising a carboxyl group that may be esterified, a carbamoyl group that may be substituted, a hydroxyl group that may be substituted, an amino group that may be substituted, or an optionally substituted heterocyclic group having a hydrogen atom that may be deprotonated; ring A represents a benzene ring that may be substituted or a heterocyclic ring that may be substituted; ring J' represents a 7- or 8-membered heterocyclic ring having at most 3 hetero-atoms as ring constituent members; and ring J' may have a further substituent in addition to R1, R2, R3 and X', or a pharmacologically acceptable salt thereof. The composition has a plasma triglyceride concentration-lowering activity, and therefore is useful for the prophylaxis or treatment of hyperlipemia, such as hypertriglyceridemia.
Sugiyama Yasuo
Yukimasa Hidefumi
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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