Antiidiotypic monoclonal antibodies

Details Antiidiotypic monoclonal antibodies Antiidiotypic monoclonal antibodies

C - Chemistry, Metallurgy

12

P

167/139, 167/37,

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/42 (2006.01) C12N 5/28 (2006.01) G01N 33/577 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2029714

4-17819/+/FER Novel antiidiotypic monoclonal antibodies Abstract of the disclosure The invention concerns murine antiidiotypic monoclonal antibodies which are the internal image of determinants recognized by a monoclonal antibody on high molecular weight-melanoma associated antigen (HMW-MAA), antibody derivatives, hybridoma cell lines secreting such antiidiotypic monoclonal antibodies, and processes for the preparation of such antiidiotypic monoclonal antibodies, of their derivatives and of the hybridoma cell lines. The murine antiidiotypic monoclonal antibodies are useful for the determination of antibodies directed against high molecular weight-melanoma associated antigen, for the modulation of the immune response to HMW-MAA and for the treatment of melanoma.

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