Antiinflammatory 17-spiroandrostenes

Details Antiinflammatory 17-spiroandrostenes Antiinflammatory 17-spiroandrostenes

C - Chemistry, Metallurgy

07

J

260/9

C07J 21/00 (2006.01) C07J 1/00 (2006.01) C07J 33/00 (2006.01) C07J 43/00 (2006.01)

Patent

CA 1226277

ABSTRACT 17-SPIROANDROSTENES Topical antiinflammatory activity is exhibited by steroids having the formula Image and the 1,2-dehydro and 15,16-dehydro derivatives thereof, wherein R1 is hydrogen, alkyl, carboxyl, or alkoxy- carbonyl; R2 is hydrogen, chlorine, bromine, fluorine, methyl, hydroxyl or a conventional hydrolyzable ester thereof, methoxy, or oxo (=O); R3 is carbonyl or .beta.-hydroxymethylene; R4 is hydrogen or fluorine; R5 is hydrogen, methyl or fluorine; X and Y are the same or different, and each is S, O, NH, N-CH3, SO or SO2; and n is 1, 2, 3, 4 or 5.

427070

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