Antiinflammatory and immunoregulatory pyridines and pyrimidines

Details Antiinflammatory and immunoregulatory pyridines and pyrimidines Antiinflammatory and immunoregulatory pyridines and pyrimidines

C - Chemistry, Metallurgy

07

D

260/251, 260/291

C07D 213/32 (2006.01) C07D 213/55 (2006.01) C07D 213/65 (2006.01) C07D 239/26 (2006.01)

Patent

CA 1156231

ABSTRACT OF THE DISCLOSURE A series of 4-(2-hydroxyethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable acid addition salts, having immunoregulatory activity are disclosed. Preferred compounds include 4-(2-hydroxyethylthiomethyl)pyridine itself, as well as 4-(2-hydroxyphenylthiomethyl)pyridine, 4-(2-hydroxy-1-propylthiomethyl)pyridine, 4-(3-hydroxy-2- butylthiomethyl)pyridine, 4-(2-hydroxyethylthiomethyl)pyrimidine, the acetate esters corresponding to the above compounds, and 4-(2,3-dihydroxy-1-propylthiomethyl)pyridine.

362238

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