Antiinflammatory imidazothiazoles

Details Antiinflammatory imidazothiazoles Antiinflammatory imidazothiazoles

A - Human Necessities

61

K

167/220, 167/234

A61K 31/505 (2006.01) A61K 31/425 (2006.01)

Patent

CA 1127084

ABSTRACT OF THE DISCLOSURE Certain imidazothiazoles and thiazolopyrimidines have been found to prevent and inhibit the formation of granuloma tissue in animals. This result is accomplished by administering to the animal subject a therapeutically effective amount of a compound having the formula: Image wherein R is hydrogen or methyl, R' is hydrogen, lower alkyl or thioalkyl, carboxy methyl, or phenyl; R" is lower alkyl, 2-benzofuranyl, naphthyl, phenyl, or mono- or disubstituted phenyl. The hydrated precursors of certain of these compounds as well as the acid addition and quaternary salts of both the compounds and their hydrated precursors may he employed.

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