Antiischemic-piperazinyl and piperidinyl-cyclohexanes

Details Antiischemic-piperazinyl and piperidinyl-cyclohexanes Antiischemic-piperazinyl and piperidinyl-cyclohexanes

C - Chemistry, Metallurgy

07

D

C07D 295/00 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 209/14 (2006.01) C07D 211/18 (2006.01) C07D 213/38 (2006.01) C07D 215/20 (2006.01) C07D 277/64 (2006.01) C07D 295/03 (2006.01) C07D 295/073 (2006.01) C07D 295/096 (2006.01) C07D 295/116 (2006.01) C07D 317/58 (2006.01) C07D 333/20 (2006.01) C07D 401/06 (2006.01) C07D 403/08 (2006.01) C07D 405/08 (2006.01) C07D 409/06 (2006.01) C07D 417/08 (2006.01)

Patent

CA 2091204

Novel piperazinyl- and piperidinyl cyclohexenes are useful in the treatment of ischemia-induced disorders, e.g., stroke, and for the treatment of psychosis. Useful compounds conform to Formula I Image (I) wherein R = R1 and is independently H or halogen; or R and R1 may be taken together to form an - O(CH2.)mO- (m = 1 or 2); X = a phenyl residue; Y = N; R2 = R3 and is independently H or C1-4 alkyl; and R4 = phenyl or substituted phenyl wherein the phenyl group is mono-, di- or di-substituted with groups selected from: F, Cl, I and C1-4 alkoxy. Compounds of Formula I include all pharmaceutically acceptable salts and/or hydrates thereof. The invention also encompasses all stereoisomers of compounds of Formula I.

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