Antimalarial compounds with flexible side-chains

Details Antimalarial compounds with flexible side-chains Antimalarial compounds with flexible side-chains

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 33/06 (2006.01) C07D 239/48 (2006.01)

Patent

CA 2700880

The present invention relates to novel compounds that are inhibitors of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which are useful for the treatment of malaria. It also relates to processes of making and using such compounds. The antimalarial compounds of the present invention have low toxicity to a host infected with the malarial parasite, and are potent when administered in pharmaceutical compositions.

Cette invention concerne de nouveaux composés qui sont inhibiteurs du type sauvage et mutant de la dihydrofolate réductase (DHFR) de Plasmodium falciparum, qui sont utilisés dans le traitement de la malaria. L'invention concerne également des procédés de fabrication et d'utilisation de ces composés. Les composés antimalariens de l'invention ont une toxicité faible vis-à-vis d'un hôte infecté par le parasite malarien, et sont puissants lorsqu'ils sont administrés dans des compositions pharmaceutiques.

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