C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/16 (2006.01) A61K 31/47 (2006.01) C07D 217/02 (2006.01) C07D 217/04 (2006.01)
Patent
CA 2183247
The present invention provides new antimalarial compounds called korupensamines, korupensamine derivatives, and pharmacologically acceptable salts thereof, methods for isolating such antimalarial korupensamines from the plant Ancistrocladus korupensis, methods for obtaining new korupensamine derivatives, antimalarial compositions containing such antimalarial korupensamines or derivatives thereof or pharmacologically acceptable salts thereof, and methods of using such antimalarial compounds for the prevention of malaria infections or for treating mammals with mammals infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.
La présente invention concerne de nouveaux composés antipaludiques dénommés "korupensamines", des dérivés des korupensamines et leurs sels pharmaceutiquement acceptables. L'invention concerne également, des procédés permettant d'isoler ces korupensamines antipaludiques à partir d'une plante, la "Ancistrocladus korupensis" ainsi que des procédés d'obtention de nouveaux dérivés des korupensamines, d'obtention de compositions contenant lesdites korupensamines antipaludiques ou leurs dérivés ou sels pharmaceutiquement acceptables, substances permettant la prévention du paludisme ou le traitement des mammifères atteints d'infections paludéennes. Les composés antipaludiques de la présente invention agissent in vitro et in vivo par inhibition de la reproduction et de la cytopathicité des parasites de l'espèce Plasmodium.
Boyd Michael R.
Bringmann Gerhard
Cardellina John H. II
Francois Guido
Hallock Yali F.
Department O. F. Health And Human Services The United States Of America Represented By The Secretary
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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