Antimicrobial agents and anticancer agents

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/407 (2006.01) A61K 31/403 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2518748

An antibacterial agent or anticancer agent which contains as an active ingredient a fullerene derivative in which two or more pairs of adjacent carbon atoms bonded to each other which are among the carbon atoms constituting the carbon cluster skeleton of a fullerene each has an organic structure bonded thereto which is represented by the formula (I) (wherein A and B represent adjacent carbon atoms bonded to each other; R1 and R2 are the same or different and each represents an optionally substituted hydrocarbon group; R3 and R4 are the same or different and each represents hydrogen or an optionally substituted hydrocarbon group; and X represents an anion). The antibacterial and anticancer agents are novel and contain as an active ingredient the fullerene derivative, which has high antibacterial activity and anticancer activity.

L'invention concerne un agent antibactérien ou un agent anticancéreux qui contient en tant que principe actif un dérivé de fullerène dans lequel deux paires d'atomes de carbone adjacents ou d'avantage, liés l'un à l'autre, lesquels sont parmi les atomes constituant le squelette d'amas de carbone d'un fullerène, chacun ayant une structure organique liée à celui-ci, lequel est représenté par la formule (I) (dans laquelle A et B représentent des atomes de carbone adjacents liés l'un à l'autre ; R?1¿ et R?2¿ sont identiques ou différents et représentent chacun un groupe hydrocarbure facultativement substitué ; R?3¿ et R?4¿ sont identiques ou différents et représentent chacun hydrogène ou un groupe hydrocarbure facultativement substitué ; et X représente un anion). Les agents antibactériens et anticancéreux sont nouveaux et il contiennent en tant que principe actif le dérivé de fullerène, lequel présente une activité antibactérienne et une activité anticancéreuse élevées.

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