Antimicrobial agents from streptococcus mitis and...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/315 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2556351

An antibacterial peptide obtainable from a S. mitis and S.oralis; or a variant thereof, or a fragment of any of these, for use as an antibacterial agent. Specific peptides have been identified. These peptides are secreted by strains of S. mitis or S. oralis. They are active against inter alia gram negative bacteria and Staphylococcal spp. The peptides may be isolated for use or the S. mitis or S. oralis may be used in a probiotic therapy.

L'invention concerne un peptide antibactérien issu d'un <I>S.</I> mitis et S. oralis ; ou une variante dudit peptide ou un fragment d'un de ces constituants, s'utilisant comme agent antibactérien. Des peptides spécifiques ont été identifiés. Ces peptides sont sécrétés par des souches de S. mitis ou de S. oralis. Ils sont actifs à l'encontre, entre autres, de bactéries Gram négatif et du Staphylococcus spp. Lesdits peptides peuvent être isolés pour être utilisés ou le S. mitis ou le S. oralis peut être utilisé dans une thérapie probiotique.

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