Antimicrobial and anticancer lipopeptides

A - Human Necessities – 61 – K

Patent

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A61K 38/00 (2006.01)

Patent

CA 2529125

The invention provides lipophilic conjugates comprising a peptide coupled to a fatty acid, the peptide comprising at least two positively charged amino acid residues, said peptide after conjugation to the fatty acid possessing antibacterial, antifungal, and/or anticancer activity higher than prior to conjugation. The lipophilic conjugates are suitable for treatment of infections caused by pathogenic organisms such as bacteria and fungi. The lipophilic conjugates are also suitable for sanitation, as disinfectants, or for food preservation.

La présente invention concerne des conjugués lipophiles comprenant un peptide couplé à un acide gras, le peptide comprenant au moins deux radicaux acide aminé chargés positivement, et ledit peptide possédant, après conjugaison en acide gras, une activité antibactérienne, antifongique et/ou anticancéreuse, supérieure à celle qu'il avait avant conjugaison. Les conjugués lipophiles conviennent au traitement d'infections provoquées par des organismes pathogènes tels que les bactéries et les champignons. Les conjugués lipophiles conviennent également à l'utilisation en tant que désinfectants, et pour la conservation alimentaire.

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