Antimicrobial and radioprotective compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 317/52 (2006.01) A61K 31/36 (2006.01) A61K 31/4184 (2006.01) A61P 31/00 (2006.01) A61P 31/04 (2006.01) A61P 31/06 (2006.01) A61P 31/08 (2006.01) A61P 31/10 (2006.01) A61P 39/00 (2006.01) C07D 235/06 (2006.01) C07D 235/08 (2006.01) C07D 263/56 (2006.01) C07D 317/50 (2006.01)

Patent

CA 2450121

The present invention relates to a method of treatment and/or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which X and Y are either the same or different and selected from a heteroatom; is a double or single bond depending on the heteroatoms X and Y; R1 to R5 are either the same or different and selected from hydrogen or a non-deleterious substituent; and R6 and R7 are either the same or different and selected from hydrogen and a non-deleterious substituent or one of R6 and R7 are absent when there is a double bond present, pharmaceutically acceptable salts or derivatives, pro-drugs, tautomers and/or isomers thereof. The present invention also relates to a method for protecting a subject from radiation damage, a method of cancer radiotherapy and use as an antimicrobial or radioprotective agent of the compound of formula (I) defined above. Some of the compounds of formula (I) are novel and are also described in the present invention, together with pharmaceutical or veterinary compositions containing them.

L'invention concerne un procédé de traitement et/ou de prophylaxie d'une infection microbienne, qui consiste à administrer une dose efficace d'un composé de la formule I, dans laquelle X et Y sont identiques ou différents et choisis dans un hétéroatome; " " est une liaison double ou simple en fonction des hétéroatomes X et Y; R¿1? à R¿5? sont soit identiques, soit différents et choisis dans l'hydrogène ou un substituant non délétère; et R¿6? et R¿7? sont soit identiques, soit différents et choisis dans hydrogène ou un substituant non délétère, ou, en présence d'une liaison double, l'un des deux R¿6? et R¿7? est absent, des sels ou des dérivés pharmaceutiquement acceptables, des promédicaments et/ou leurs isomères. L'invention concerne également un procédé permettant de protéger un patient contre des dommages causés par le rayonnement, un procédé de radiothérapie cancéreuse, ainsi que l'utilisation d'un agent antimicrobien ou radioprotecteur du composé de la formule I définie ci-dessus. L'invention concerne certains composés de la formule I nouveaux qui font également l'objet d'une description, ainsi que des compositions pharmaceutiques ou vétérinaires les contenant.

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