Antimicrobial biguanide metal complexes

C - Chemistry – Metallurgy – 07 – F

Patent

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C07F 1/10 (2006.01)

Patent

CA 2613005

A compound comprising a metal species and a biologically acceptable llgand, wherein the biologically acceptable ligand comprises a biguanide moiety, and wherein the biologically acceptable ligand forms a complex with the metal species in which the metal species is stabilised in an oxidation state greater than 1+. Compositions and medical devices comprising the compound. A method for the treatment or prophylaxis of microbial, including bacterial, infections, comprising the use of such compounds, compositions or medical devices.

La présente invention concerne un composé comprenant une espèce métallique et un ligand biologiquement acceptable. Le ligand biologiquement acceptable comprend un groupe fonctionnel biguanide, et forme un complexe avec l~espèce métallique dans lequel l~espèce métallique est stabilisée dans un état d~oxydation supérieur à 1+. L~invention a également trait aux compositions et appareils médicaux renfermant ce composé, ainsi qu~au procédé destiné au traitement ou à la prophylaxie d~infections microbiennes, comprenant les infections bactériennes, utilisant de tels composés, compositions ou appareils médicaux.

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