C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/195 (2006.01)
Patent
CA 2632782
The invention relates to antimicrobial cathelicidin polypeptides related to a 38 amino acid peptide having SEQ ID NO:4. The invention provides for polypeptides having broad spectrum antimicrobial activity, nucleic acids and expression vectors encoding such polypeptides, as well as host cells and methods of reducing survival of a microbe. In addition, the invention also provides compositions, as well as articles of manufacture, that comprise a broad spectrum antimicrobial polypeptide.
L'invention porte: sur des polypeptides antimicrobiens de cathélicidine parents d'un peptide de 38 acides aminés comprenant la SEQ ID NO:4; sur des polypeptides présentant une activité antimicrobienne à large spectre, sur des acides nucléiques et des vecteurs d'expression codant pour de tels polypeptides; sur des cellules hôtes et des méthodes de réduction de la survie d'un microbe, et sur des compositions et articles manufacturés comprenant un large spectre de ces polypeptides antimicrobiens.
Blecha Frank
Melgarejo Tonatiuh
Ortega Maria Teresa
Sang Yongming
Gowling Lafleur Henderson Llp
Kansas State University Research Foundation
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