C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2222599
A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH2-KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH2-KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (SEQ ID NO:2). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxaemia in a subject.
La présente invention concerne une classe nouvelle de peptides cationiques ayant des propriétés antimicrobiennes. Parmi ces peptides, on peut citer: NH¿2?-KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (n· d'ident. de séquence: 1) et NH¿2?-KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (n· d'ident. de séquence: 2). L'invention concerne aussi des procédés d'inhibition de la croissance de bactéries dans lesquels les peptides de l'invention sont utilisés. Ces peptides sont particulièrement utiles pour inhiber l'endotoxémie chez un sujet.
Hancock Robert E.w.
Karunaratne Nedra
Mbm & Co.
University Of British Columbia
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