C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2230160
A novel class of cationic peptides having antimicrobial activity is disclosed. These peptides can be encompassed by the formulas: X1X1PX2X3X2P(X2X2P)nX2X3(X5)o (SEQ ID NO: 23); X1X1PX2X3X4(X5)rPX2X3X3 (SEQ ID NO: 24); X1X1X3(PW)uX3X2X5X2X2X5X2(X5)o (SEQ ID NO: 25); X1X1X3X3X2P(X2X2P)nX2(X5)m (SEQ ID NO: 26); wherein m is 1 to 5; n is 1 or 2; o is 2 to 5; r is 0 to 8; u is 0 or 1; X1 is Isoleucine, Leucine, Valine, Phenylalanine, Tyrosine, Tryptophan or Methionine; X2 represents Tryptophan or Phenylalanine; X3 represents Arginine or Lysine; X4 represents Tryptophan or Lysine; and X5 represents Phenylalanine, Tryptophan, Arginine, Lysine or Proline. The invention also provides a method of producing a cationic peptide variant having antimicrobial activity.
Nouvelle classe de peptides cationiques présentant une activité antimicrobienne. Ces peptides peuvent être représentés par les formules suivantes: X¿1?X¿1?PX¿2?X¿3?X¿2?P(X¿2?X¿2?P)¿n?X¿2?X¿3?(X¿5?)¿o? (SEQ ID NO: 23); X¿1?X¿1?PX¿2?X¿3?X¿4?(X¿5?)¿r?PX¿2?X¿3?X¿3? (SEQ ID NO: 24); X¿1?X¿1?X¿3?(PW)¿u?X¿3?X¿2?X¿5?X¿2?X¿2?X¿5?X¿2?(X¿5?)¿o?(SEQ ID NO: 25); X¿1?X¿1?X¿3?X¿3?X¿2?P(X¿2?X¿2?P)¿n? X¿2?(X¿5?)¿m? (SEQ ID NO: 26); dans lesquelles m est un nombre de 1 à 5, n vaut 1 ou 2, o est un nombre de 2 à 5, r est un nombre de 0 à 8, u vaut 0 ou 1, X¿1? représente isoleucine, leucine, valine, phénylalanine, tyrosine, tryptophane ou méthionine, X¿2? représente tryptophane ou phénylalanine, X¿3? représente arginine ou lysine, X¿4? représente tryptophane ou lysine et X¿5? représente phénylalanine, tryptophane, arginine, lysine ou proline. L'invention concerne également un procédé de production d'un peptide cationique variant présentant une activité antimicrobienne.
Falla Timothy J.
Gough Monisha
Hancock Robert E.w.
Mbm Intellectual Property Law Llp
The University Of British Columbia
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