A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/737 (2006.01) A61K 31/715 (2006.01) A61K 31/727 (2006.01) A61P 31/00 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) A61P 31/12 (2006.01)
Patent
CA 2495116
Methods and compositions for treating or preventing microbial infection in mammals with sulfated polysaccharides wherein the polysaccharides have a degree of sulfation effective to enable maximal interaction of constituent sulfate groups with the microbe which causes the infection and wherein the sulfated polysaccharide is not substantially endocytosed or degraded by cell receptor binding in the mammal and thereby retains antimicrobial activity in vivo.
L'invention concerne des procédés et des compositions destinés au traitement et à la prévention d'infections microbiennes chez des mammifères, au moyen de polysaccharides sulfatés. Lesdits polysaccharides présentent un degré de sulfatation suffisant pour permettre une interaction maximale de groupes sulfates constituants avec le microbe responsable de l'infection. Par ailleurs, le polysaccharide sulfaté n'est pas entièrement endocytosé ou dégradé par liaison de récepteurs cellulaires dans le mammifère et conserve par conséquent une activité antimicrobienne <i>in vivo</i>.
Comper Wayne D.
Monash University
Osler Hoskin & Harcourt Llp
LandOfFree
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