Antimicrobial compositions containing 1-ethyl-6-...

A - Human Necessities – 61 – K

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167/120, 167/223

A61K 31/495 (2006.01) A61K 31/505 (2006.01)

Patent

CA 1219527

ANTIMICROBIAL COMPOSITIONS CONTAINING 1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7- (1-PIPERAZINYL)-3-QUINOLINE CARBOXYLIC ACID OR METAL SALTS THEREOF AND SILVER SULFADIAZINE ABSTRACT OF THE DISCLOSURE Compositions which include 1-ethyl-6-fluoro-1,4-dihydro-4- oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or its metal salts, e.g., silver, zinc, cobalt or cerium salts, and silver sulfadiazine are effective in the treatment of burns. Of special interest are compositions containing silver sulfa- diazine and the silver salt of the above-identified quino- line carboxylic acid, wherein even though each compound is present in a concentration which would be ineffective if either compound were present alone, the resulting composi- tions are effective. The compositions of this invention may be applied to the affected surface of a burn victim either directly or in combination with a physiologically ac- ceptable carrier, such as a water-dispersible, hydrophilic carrier.

436358

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