Antimicrobial compounds

Details Antimicrobial compounds Antimicrobial compounds

C - Chemistry, Metallurgy

07

C

C07C 317/24 (2006.01) A61K 31/16 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2301943

This invention provides methods for treating a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R-SO n-Z-CO-Y, where R is an alkyl group having 6-20 carbons; Z is a radical selected from -CH2-, -O-, and -NH-, two of these radicals coupled together, or -CH2-CH2- ; Y is -NH2, O-CH2-C6H5, -CO-CO-O-CH3, or O-CH3; and n is 1 or 2. It has been discovered that these compounds inhibit growth of microbial cells which synthesize .alpha.-substitued, .beta.-hydroxy fatty acids, particularly corynemycolic acid, nocardic acid, and mycolic acid. These compounds may be used to inhibit growth of mycobacterial cells, such as Mycobacterium tuberculosis, drug-resistant M. tuberculosis, M. avium intracellulare, and M. leprae.

L'invention concerne des traitements pour les infections à mycobactéries, comprenant l'administration à un animal d'une composition pharmaceutique contenant un composé représenté par la formule R-SOn-Z-CO-Y, dans laquelle R est un groupe alkyle comprenant de 6 à 20 atomes de carbone; Z est un radical sélectionné parmi -CH2-, -O- et -NH-, deux de ces radicaux assemblés ou -CH2=CH2-; Y est -NH2, O-CH2-C6H5, -CO-CO-O-CH3 ou O-CH3; et n est 1 ou 2. On a découvert que ces composés inhibent le développement des cellules microbiennes qui synthétisent les acides gras beta -hydroxy substitués en alpha , en particulier l'acide corynemycolique, l'acide nocardique et l'acide mycolique. Ces composés peuvent êtres utilisés pour inhiber le développement de cellules mycobactériennes tells que Mycobacterium tuberculosis, M. tuberculosis pharmacorésistant, M. avium intracellulare et M. leprae.

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