Antimicrobial histone h1 compositions, kits, and methods of...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A23K 1/17 (2006.01) A61K 39/39 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2379087

The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and meth- ods of using eukaryotic histone H1 protein to kill or to inhibit the growth of microorganisms, including, but not limited to, human pathogenic bacteria. The invention further includes a eukaryotic histone H1- containing animal feed and methods of improving growth of an animal by supplying the feed to the animal. The invention still further includes a kit comprising a eukaryotic histone H1-containing antibiotic pharmaceutical composition and an instructional material which describes the use of the composition. In addition, the invention includes a vaccine comprising a eukaryotic histone H1 protein and a method of vaccinating an animal using the vaccine.

L'invention concerne des compositions pharmaceutiques antibiotiques contenant une protéine de l'histone H1 eucaryote, ainsi que des modes d'emploi de ladite protéine pour tuer des micro-organismes ou inhiber leur croissance, lesdits micro-organismes comprenant, mais pas exclusivement, des bactéries pathogènes humaines. L'invention concerne également un aliment pour animal contenant l'histone H1 eucaryote, ainsi que des méthodes qui améliorent la croissance d'un animal nourri avec ledit aliment. Elle concerne en outre une trousse comprenant une composition pharmaceutique antibiotique contenant l'histone H1 eucaryote, et une notice indiquant le mode d'emploi de cette composition. Elle concerne enfin un vaccin contenant une protéine de l'histone H1 eucaryote, et une méthode pour vacciner un animal avec ledit vaccin.

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