Antimicrobial imidazole derivatives

Details Antimicrobial imidazole derivatives Antimicrobial imidazole derivatives

C - Chemistry, Metallurgy

07

D

6/14, 260/305, 2

C07D 233/60 (2006.01) A01N 43/50 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1183855

ABSTRACT The invention is concerned with novel dithioketal derivatives of 1-(2-aryl-2-oxoethyl)-1H-imidazoles and sulfones and sulfoxides derived therefrom, said compounds being useful as antimicrobial agents. These novel compounds may be represented by the formula: Image (I), the possible stereochemically isomeric forms, the acid addition salts and the metal complexes thereof, wherein: R1 and R2 are each independently selected from the group consisting of hydrogen, halo and methyl; R3 and R4 are each independently selected from the group consisting of C1-C6-lower alkyl and C3-C4-lower alkenyl, or R3 and R4 form, together with the sulfur atoms to which they are attached and the bridging carbon atom, a 5, 6 or 7-membered ring which is optionally substituted with 1 to 4 C1-C4-lower alkyl groups; R5 is a member selected from the group consisting of hydrogen, C1- C4-lower alkyl, 2-propenyl and 2-propynyl; and n is 0, 1 or 2.

397116

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