C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 17/10 (2006.01) A61K 31/405 (2006.01) C07D 209/10 (2006.01)
Patent
CA 2172854
The invention is drawn to an antibiotic, NEMATOPHIN, 3-indoleethyl 2-oxo-3- methylbutanamide (+ stereoisomer, - stereoisomer and racemic mixture) and its derivatives, 3- indoleethyl 2-oxo-alkanamides, 3-indoleethyl 2-oxo-alkanoates with or without substitute(s) on the indole ring, produced by bacterial symbiont Xenorhabdus nematophilus and/or other Xenorhabdus species or synthesized by reaction of tryptamine or substituted tryptamine and 2-oxo-alkanoic acid or its derivative, the salts thereof, the pharmaceutical compositions thereof and their use as medicaments. particularly in the treatment of infectious diseases involving microorganisms susceptible to them, including antibiotic-resistant Staphylococcus.
Chen Genhui
Li Jianxiong
Webster John M.
Chen Genhui
Li Jianxiong
Oyen Wiggs Green & Mutala Llp
Webster John M.
Welichem Biotech Inc.
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