Antimicrobial lactam-quinolones

Details Antimicrobial lactam-quinolones Antimicrobial lactam-quinolones

C - Chemistry, Metallurgy

07

D

167/100, 260/104

C07D 463/00 (2006.01) C07D 215/56 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 417/14 (2006.01) C07D 455/04 (2006.01) C07D 471/04 (2006.01) C07D 477/10 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 498/06 (2006.01) C07D 499/00 (2006.01) C07D 499/86 (2006.01) C07D 501/00 (2006.01) C07D 501/34 (2006.01) C07D 503/00 (2006.01) C07D 505/00 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2001225

Antimicrobial lactam-quinolone compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: Image wherein (1) A1, A2, A3, R1, R4 and R6 generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have antimicrobial activity; and (2) R1 or R3 contain a linking moiety, linking the quinolone moiety to a lactam-containing moiety having the formula: Image wherein (3) R10, R11, R12, R13, and R14, together with bonds "a" and "b", form any of a variety of lactam-containing moieties known in the art to have antimicrobial activity; and (4) the linking moiety includes (for example) carbamate, dithiocarbamate, urea, thiourea, isouronium, isothiouronium, guanidine, carbonate, trithiocarbonate, reversed carbamate, xanthate, reversed isouronium, reversed dithiocarbamate, reversed isothiouronium, amine, imine, ammonium, heteroarylium, ether, thioether, phosphono, phosphoramide, phosphate, sulfonamide, ester, thioester, amide, and hydrazide groups.

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