Antimicrobial oil-in-water emulsions

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/56 (2006.01) A01N 25/04 (2006.01) A01N 45/00 (2006.01) A61K 9/10 (2006.01) A61K 9/127 (2006.01) A61K 31/14 (2006.01) A61K 31/23 (2006.01) A61K 31/231 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2190606

An antimicrobial oil-in-water emulsion comprising an agent selected from the group consisting of glycerol monooleate, glycerol trioleate, glycerol monolaurate, and glycerol dilaurate as the primary emulsifier and a cationic halogen-containing compound having a C12-C16 chain as a positive charge producing agent is disclosed. The emulsion can optionally further include a sterol, preferably phytosterol. Preferred cationic halogen-containing compounds having a C12-C16 chain for use in the invention include cetylpyridinium chloride, cetylpyridinium bromide, cetyltrimethylammonium bromide, cetyldimethyethylammonium bromide, and benzalkonium chloride. The antimicrobial emulsion can be used in the form of a pharmaceutical preparation to inhibit the growth of a wide variety of infectious pathogens, including bacteria, fungi, and viruses.

L'invention décrit une émulsion huile-dans-eau antimicrobienne qui contient un agent choisi dans un groupe comprenant le mono-oléate de glycérol, le trioléate de glycérol, le monolaurate de glycérol et le dilaurate de glycérol, qui sert d'émulsifiant primaire, et un composé halogéné cationique possédant une chaîne C¿12?-C¿16? qui sert d'agent producteur de la charge positive. L'émulsion peut en outre comprendre éventuellement un stérol, de préférence un phytostérol. Les composés halogénés cationiques possédant une chaîne C¿12?-C¿16? préférés pour l'invention comprennent le chlorure de cétylpyridinium, le bromure de cétylpyridinium, le bromure de cétyltriméthylammonium, le bromure de cétyldiméthyléthylammonium et le chlorure de benzalkonium. L'émulsion antimicrobienne peut être utilisée sous la forme d'une préparation pharmaceutique destinée à inhiber la croissance d'une grande variété d'agents pathogènes infectieux, notamment des bactéries, des champignons et des virus.

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