Antimicrobial peptide and an antimicrobial agent

Details Antimicrobial peptide and an antimicrobial agent Antimicrobial peptide and an antimicrobial agent

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A01N 37/18 (2006.01) C07K 14/79 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2063063

The present invention is concerned with a substantially purified and isolated peptide having antimicrobial activity which consists of an amino acid sequence selected from the group consisting of the following amino acid sequences (1)-(15): (1) Arg-Trp-Gln-Trp-Arg; (2) Arg-Arg-Gln-Trp-Arg; (3) Lys-Val-Ser-Trp-Arg; (4) Arg-Asn-Met-Arg-Lys; (5) Arg-Trp-Gln-Glu-Lys; (6) Arg-Arg-Trp-Gln-Trp-Arg; (7) Arg-Arg-Arg-Gln-Trp-Arg; (8) Lys-Thr-Val-Ser-Trp-Arg; (9) Lys-Arg-Asn-Met-Arg-Lys; (10) Arg-Trp-Gln-Glu-Met-Lys; (11) Lys-Thr-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys; (12) Lys-Ser-Arg-Arg-Arg-Gln-Trp-Arg-Met-Lys-Lys; (13) Lys-Thr-Val-Ser-Trp-Gln-Thr-Tyr-Met-Lys-Lys; (14) Lys-Thr-Phe-Gln-Trp-Gln-Arg-Asn-Met-Arg-Lys; (15) Lys-Thr-Leu-Arg-Trp-Gln-Asn-Glu-Met-Arg-Lys; and antimicrobial derivatives thereof having minor amino acid partial substitutions or additions which do not abolish the antimicrobial properties of the peptide. The peptide or derivative thereof of the invention possesses strong antimicrobial properties and has no undesirable side effects.

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