C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 38/10 (2006.01) A61K 38/48 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12N 9/76 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2145313
Peptides which exhibit antimicrobial activity comparable to certain known antibiotics are provided. These peptides are related in sequence to amino acid sequences within Cathepsin G. A broad spectrum bactericidal peptide disclosed herein is RPGTLCTVAGWGRVSMRRGT (SEQ ID NO:4); it is active against Pseudomonas aeruginosa, Neisseria gonorrhoeae and Staphylococcus aureus. RRENTQQHITARRAIRHPQY (SEQ ID NO:7) and GKSSGVPPEVFTRFVSSFLPWIRTTMR (SEQ ID NO:8) also exhibited potent activiy against P. aeruginosa strains, including clinical isolates. The peptides of the present invention will be useful in pharmaceutical compositions useful in the treatment or prophylaxis of infections.
Peptides présentant une activité antimicrobienne comparable à celle de certains antibiotiques connus. Ces peptides sont apparentés en séquence à des séquences d'acides aminés contenues dans la cathepsine G. Le peptide bactéricide à large spectre de l'invention est le suivant RPGTLCTVAGWGRVSMRRGT (SEQ ID NO:4); il est actif contre Pseudomonas aeruginosa, Neisseria gonorrhoeae et Staphylococcus aureus. RRENTQQHITARRAIRHPQY (SEQ ID NO:7) et GKSSGVPPEVFTRFVSSFLPWIRTTMR (SEQ ID NO:8) ont également présentés une activité puissante contre des souches de P. aeruginosa, y compris des isolats cliniques. Les peptides de l'invention sont utiles dans des compositions pharmaceutiques de traitement ou de prophylaxie d'infections.
Pohl Jan
Shafer William
Emory University
Mckay-Carey & Company
University Of Georgia Research Foundation Inc.
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