Antimicrobial peptides

Details Antimicrobial peptides Antimicrobial peptides

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 9/00 (2006.01) A61K 9/68 (2006.01) A61K 38/17 (2006.01) A61K 47/06 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2311389

The present invention provides antimicrobial peptides. The peptides are non- glycosylated, less than about 100 amino acids and include an amino aid sequence selected from the group consisting of AVESTVATLEAEPEVIESPPE (SEQ. ID. NO. 1), AVESTVATLEDEPEVIESPPE (SEQ. ID. NO. 2), AVESTVATLEASPEVIESPPE (SEQ. ID. NO. 3), AVESTVATLEDSPEVIESPPE (SEQ. ID. NO. 4), DMPIQAFLLYQQPVLGPVR (SEQ. ID. NO. 5), and conservative substitutions therein. These peptides can be produced synthetically, however, they can most conveniently be derived from casein.

La présente invention se rapporte à des peptides antimicrobiens. Ces peptides sont non-glycosylés, ils contiennent moins de 100 acides aminés et comprennent une séquence d'acides aminés sélectionnée dans le groupe constitué par AVESTVATLEA.SIGMA.PEVIESPPE (SEQ. ID. NO. 1), AVESTVATLED.SIGMA.PEVIESPPE (SEQ. ID. NO. 2), AVESTVATLEASPEVIESPPE (SEQ. ID. NO. 3), AVESTVATLEDSPEVIESPPE (SEQ. ID. NO. 4), DMPIQAFLLYQQPVLGPVR (SEQ. ID. NO. 5), et des substitutions conservatrices de ces séquences. Ces peptides peuvent être produits par synthèse mais peuvent cependant être, de manière très pratique, dérivés de caséine.

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