Antimicrobial peptides derived from ubiquicidine

Details Antimicrobial peptides derived from ubiquicidine Antimicrobial peptides derived from ubiquicidine

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/04 (2006.01) A61K 38/10 (2006.01) A61K 51/08 (2006.01) C07K 5/04 (2006.01) C07K 7/04 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12N 15/11 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2291894

The invention relates to the use of ubiquicidine or optionally modified peptide fragments derived therefrom for the preparation of a drug for the treatment, diagnostics or prophylaxis of infections in humans and animals. A peptide fragment derived from ubiquicidine comprises for instance a preferably continuous series of at least 3, preferably at least 7-13 amino acids from the amino acid sequence of ubiquicidine: KVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPNANS. Hybrid molecules comprise for instance a cationic peptide with an antimicrobial action and/or a peptide fragment of ubiquicidine and/or a derivative thereof and one or more effector molecules.

Cette invention se rapporte à l'utilisation d'ubiquicidine ou de fragments peptidiques éventuellement modifiés, dérivés de l'ubiquicidine, pour la préparation d'un médicament destiné au traitement, au diagnostic ou à la prophylaxie d'infections chez des sujets humains ou animaux. Un fragment peptidique dérivé de l'ubiquicidine comporte par exemple une série de préférence continue d'au moins 3, de préférence au moins 7 à 13 acides aminés provenant de la séquence d'acides aminés de l'ubiquicidine, à savoir KVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPNANS. Les molécules hybrides comportent par exemple un peptide cationique doté d'une activité antimicrobienne et/ou un fragment peptidique d'ubiquicidine et/ou un dérivé d'un tel fragment et une ou plusieurs molécules effectrices.

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