Antimicrobial peptides, polypeptides comprising same,...

Details Antimicrobial peptides, polypeptides comprising same,... Antimicrobial peptides, polypeptides comprising same,...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2592034

The invention concerns novel peptides exhibiting antimicrobial properties, polypeptides comprising said peptides, methods for preparing same, polynucleotides coding for said peptides, chimeric genes, vectors containing said polynucleotides or said chimeric genes and transformed organisms. The novel inventive peptides are peptides of formula (1): C-x(3,7)-C-x(2,4)-C- x(9,10)-C-x(3,6)-CC wherein x(3,7), x(2,4), x(9,10) and x(3,6), do not have the same values at the same time forming the peptide sequences defined by the following five formulae: (1A), (1B), (1C), (1D), and (1E): (1A): C-x(2)-x- x(1,5)-C-[RKQET]-x(2,3)-C-x(3)-[EDNL]-x(5,6)-C-x(3,6)-CC (1B): C-x(3)-G-x(2)-C- x(3,4)-C-x(9,10)-C-x(2,5)-KCC (1C): C-x(4)-G-x-C-x(3,4)-C-x(7,8)-[ASG]- [TSNHKL]-C-x(5,6)-CC (1D): C-[LVIF]-[QE]-x(4)-C-x(3,4)-C-x(9,10)-C-Y-x(2)-[KR]- G-x-CC (1E): C-M-x(2)-G-x(2)-CWGPC-x(9)-C-x(6)-CC.

L'invention concerne de nouveaux peptides présentant des propriétés antimicrobiennes, des polypeptides comprenant lesdits peptides, des procédés pour les préparer, des polynucléotides codant pour lesdits peptides, des gènes chimères, des vecteurs contenant lesdits polynucléotides ou lesdits gènes chimères et des organismes transformés. Les nouveaux peptides selon l'invention sont les peptides de formule (1): C-x(3,7)-C-x(2,4)-C-x(9,10)-C-x(3,6)-CC dans laquelle: x(3,7), x(2,4), x(9,10) et x(3,6), ne prennent pas en même temps les valeurs formant les séquences peptidiques définies par les cinq formules (1A), (1B), (1C), (1D), et (1E) suivantes : (1A): C-x(2)-x-x(1,5)-C-[RKQET]-x(2,3)-C-x(3)-[EDNL]-x(5,6)-C-x(3,6)-CC (1B): C-x(3)-G-x(2)-C-x(3,4)-C-x(9,10)-C-x(2,5)-KCC (1C): C-x(4)-G-x-C-x(3,4)-C-x(7,8)-[ASG]-[TSNHKL]-C-x(5,6)-CC (1D): C-[LVIF]-[QE]-x(4)-C-x(3,4)-C-x(9,10)-C-Y-x(2)-[KR]-G-x-CC (1E): C-M-x(2)-G-x(2)-CWGPC-x(9)-C-x(6)-CC.

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