Antimicrobial phenazine compounds

Details Antimicrobial phenazine compounds Antimicrobial phenazine compounds

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 31/498 (2006.01)

Patent

CA 2247348

Phenazine compounds having antimicrobial activity are described. The phenazine compounds can be phenazine N-oxides, including phenazine-5,10-dioxides, which may optionally be substituted at one or more positions, preferably the 7- and/or 8-positions of the phenazine nucleus. Also described are methods for treating microbial infections, and methods for inhibiting the growth of a microbial cell. The microbes treated or inhibited can be multidrug resistant. These compounds also inhibit the growth of tumor cells.

Composés de phénazine à activité antimicrobienne, pouvant être des N-oxydes de phénazine, y compris des 5,10-dioxydes de phénazine, qui peuvent être éventuellement substitués à une ou plusieurs positions, de préférence les positions 7- et/ou 8- du noyau phénazine. Des méthodes de traitement d'infections microbiennes et des méthodes permettant d'inhiber la croissance d'une cellule microbienne sont également décrites. Les microbes traités ou inhibés peuvent présenter une résistance multiple aux médicaments.

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